{"id":10252,"date":"2022-12-16T11:31:00","date_gmt":"2022-12-16T03:31:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252"},"modified":"2022-12-16T11:31:00","modified_gmt":"2022-12-16T03:31:00","slug":"%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252","title":{"rendered":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e5<\/span><span class=\"legendSpanClass\">2022\u5e7412\u670816\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5c07\u8207\u7f85\u6c0f\u958b\u5c55\u4e00\u9805\u96a8\u6a5f\u8de8\u570b\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5929\u6f14\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u55ae\u6297\uff08\u6297PD-L1\u55ae\u514b\u9686\u6297\u9ad4\uff09\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\uff08\u6297VEGF\u55ae\u514b\u9686\u6297\u9ad4\uff09\u4e4b\u4e09\u806f\u514d\u75ab\u7642\u6cd5\u91dd\u5c0d\u665a\u671f\u809d\u7d30\u80de\u764c\uff08hepatocellular carcinoma, HCC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\u3002\u672c\u6b21\u5408\u4f5c\u5c07\u4f7f\u7528\u7f85\u6c0f\u7684MORPHEUS-LIVER\u5e73\u53f0\uff0c\u4ee5\u5be6\u73fe\u5feb\u901f\u9ad8\u6548\u7684\u806f\u5408\u958b\u767c\u3002<\/p>\n<p>\u672c\u6b21\u5408\u4f5c\u5c07\u7531\u7f85\u6c0f\u8cc7\u52a9\uff0c\u521d\u671f\u8a08\u5283\u572860\u540d\u665a\u671f\u809d\u764c\u60a3\u8005\u4e2d\u958b\u5c55\u96a8\u6a5fIb\/II\u671f\u8de8\u570b\u591a\u4e2d\u5fc3\u8a66\u9a57\uff0c\u8a55\u4f30ADG126\u8207\u8c9d\u4f10\u73e0\u55ae\u6297\u548c\u963f\u66ff\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5c0d\u7167\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u8207\u85e5\u4ee3\u52d5\u529b\u5b78\u3002\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5169\u5bb6\u516c\u53f8\u5c07\u63d0\u4f9b\u5404\u81ea\u7684\u6297\u764c\u85e5\u7269\u3002\u5929\u6f14\u5c07\u4fdd\u7559\u5c0dADG126\u7684\u5168\u7403\u958b\u767c\u8207\u5546\u54c1\u5316\u6b0a\u5229\u3002\u95dc\u65bc\u672c\u6b21\u5408\u4f5c\u7684\u5176\u4ed6\u8ca1\u52d9\u8a73\u60c5\u4e26\u672a\u516c\u4f48\u3002<\/p>\n<p>\u672c\u6b21\u7814\u7a76\u5c07\u5929\u6f14\u7684\u5168\u7403ADG126\u81e8\u5e8a\u958b\u767c\u62d3\u5c55\u5230\u809d\u764c\u4e00\u7dda\u6cbb\u7642\uff0c\u6709\u671b\u6210\u70ba\u809d\u7d30\u80de\u764c\u4e00\u7dda\u806f\u5408\u7642\u6cd5\u4e2d\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002\u76ee\u524d\u6297CTLA-4\u8207\u6297PD-1\/PD-L1\u806f\u5408\u7642\u6cd5\u5df2\u5728\u81e8\u5e8a\u4e0a\u8868\u73fe\u51fa\u6709\u7d71\u8a08\u5b78\u5dee\u7570\u7684\u81e8\u5e8a\u7372\u76ca\u3002\u6b63\u5728\u9032\u884c\u4e2d\u7684Ib\/II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5df2\u8868\u660e\uff0c\u5728\u55ae\u4e00\u6cbb\u7642\u6700\u9ad8\u5291\u91cf20 mg\/kg\u91cd\u8907\u7d66\u85e5\u548c\u5728\u806f\u5408\u5291\u91cf\u9ad8\u905410 mg\/kg\u8207\u6297PD-1\u7684\u806f\u5408\u6cbb\u7642\u4e2d\uff0cADG126\u986f\u73fe\u51fa\u9ad8\u5ea6\u5dee\u7570\u5316\u7684\u5b89\u5168\u6027\u3002\u6191\u501f\u91cd\u8907\u7d66\u85e5\u5f8c\u512a\u7570\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u7a4d\u6975\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0cADG126\u975e\u5e38\u9069\u7528\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u91dd\u5c0d\u816b\u7624\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<p>\u300c\u7f85\u6c0f\u958b\u767c\u7684\u96d9\u85e5\u806f\u5408\u7642\u6cd5\u662fFDA\u5be9\u6279\u901a\u904e\u7684\u809d\u764c\u7684\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u8207\u4ed6\u5011\u570d\u7e5e\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u958b\u555f\u672c\u6b21\u5408\u4f5c\uff0c\u5728\u73fe\u6709\u7684\u7a81\u7834\u6027\u7684\u4e8c\u91cd\u806f\u5408\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u4e4b\u5916\u63a2\u7d22\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5728\u4e09\u91cd\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\uff0c\u300d\u5929\u6f14\u806f\u5408\u5275\u59cb\u4eba\u3001\u9996\u5e2d\u57f7\u884c\u5b98\u517c\u8463\u4e8b\u9577\u7f85\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff0c\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u91dd\u5c0d\u809d\u764c\u7684\u591a\u85e5\u806f\u5408\u65b9\u6848\u4e00\u76f4\u9762\u81e8\u5b89\u5168\u6311\u6230\uff0c\u800c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5c55\u793a\u4e86\u6297CTLA-4\u7642\u6cd5\u524d\u6240\u672a\u6709\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5c07\u5176\u52a0\u5165\u4e09\u91cd\u514d\u75ab\u806f\u5408\u7642\u6cd5\u662f\u4e00\u500b\u9817\u5177\u524d\u666f\u7684\u809d\u764c\u6cbb\u7642\u7b56\u7565\uff0c\u6211\u5011\u5c0d\u6b64\u5145\u6eff\u671f\u5f85\u3002\u300d<\/p>\n<p>\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u53ef\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5f9e\u800c\u89e3\u6c7a\u773e\u591a\u6297\u9ad4\u7642\u6cd5\u9762\u81e8\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u6311\u6230\u3002\u5b89\u5168\u6297\u9ad4ADG126\u5c07\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297CTLA-4\u6297\u9ad4ADG116\uff0c\u4ee5\u5be6\u73fe\u5b89\u5168\u6297\u9ad4ADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\uff08therapeutic index\uff09\u5f9e\u800c\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u7642\u6cd5\u4e2d\u5b58\u5728\u7684\u5b89\u5168\u554f\u984c\u3002<\/p>\n<p>\u63a9\u853d\u578bADG126\u6240\u7d50\u5408\u7684CTLA-4\u9776\u9ede\u7684\u7368\u7279\u8868\u4f4d\u8207ADG116\u76f8\u540c\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5728\u816b\u7624\u7d44\u7e54\u4e2d\u7684\u66b4\u9732\u5f9e\u800c\u589e\u5f37\u4f5c\u7528\uff0c\u4ee5\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002<\/p>\n<p>\u95dc\u65bc\u809d\u7d30\u80de\u764c<\/p>\n<p>\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e94\u5e38\u898b\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u81f4\u6b7b\u75c5\u56e0\uff0c\u6bcf\u5e74\u65b0\u589e854,000\u500b\u75c5\u4f8b\uff0c\u9020\u6210810,000\u4eba\u6b7b\u4ea1\u3002\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u662f\u6700\u4e3b\u8981\u7684\u539f\u767c\u6027\u809d\u764c\uff0c\u5728\u6240\u6709\u539f\u767c\u6027\u809d\u81df\u60e1\u6027\u816b\u7624\u4e2d\u5360\u6bd4\u7d0490%\u3002\u7531\u65bc\u75c7\u72c0\u986f\u9732\u9072\u7de9\uff0c\u591a\u905480%\u7684\u809d\u7d30\u80de\u764c\u5728\u78ba\u8a3a\u5f8c\u6703\u767c\u5c55\u6210\u70ba\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u8f49\u79fb\u6027\u764c\u75c7\u3002\u7d55\u5927\u591a\u6578\u809d\u7d30\u80de\u764c\u60a3\u8005\u90fd\u4f34\u6709\u6f5b\u5728\u809d\u786c\u5316\u75c7\u72c0\uff0c\u9700\u8981\u540c\u6642\u6cbb\u7642\u60e1\u6027\u816b\u7624\u8207\u809d\u786c\u5316\uff0c\u56e0\u6b64\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u8907\u96dc\u96e3\u6cbb\u7684\u75be\u75c5\u3002\u5728\u7f8e\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\uff08OS\uff09\u7387\u70ba17%\uff08Siegel\u7b49\uff0c2016\u5e74\uff09\uff1b\u5728\u4e2d\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\u7387\u70ba10.1%\uff08Chen\u7b49\uff0c2016\u5e74\uff09\u3002\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u6975\u70ba\u81f4\u547d\u7684\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u8207\u767c\u75c5\u7387\u4e4b\u6bd4\u9054\u52300.98\uff0c\u5728\u5be6\u9ad4\u816b\u7624\u4e2d\u9ad8\u5c45\u7b2c\u4e00\uff08Kamangar\u7b49\uff0c2006\u5e74\uff09\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u4f30\u6e2c\uff0c2030\u5e74\u5c07\u6709\u8d85\u904e100\u842c\u4eba\u6b7b\u65bc\u809d\u764c\uff0c\u9020\u6210\u5168\u7403\u91cd\u5927\u516c\u5171\u885b\u751f\u554f\u984c\uff08Villanueva 2019\uff09\u3002<\/p>\n<p>\u5b89\u5168\u6e2f\u8072\u660e<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b1995\u5e74\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u4e0b\u6240\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\uff0c\u5305\u62ecADG126\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u548c\u7f85\u6c0f\u4e4b\u9593\u5546\u696d\u5408\u4f5c\u5b89\u6392\u7684\u9810\u671f\u6536\u76ca\u548c\u6f5b\u529b\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1bCOVID-19 \u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u4ee520-F\u70ba\u5f62\u5f0f\u76842021\u5e74\u5ea6\u5831\u544a\u4e4b\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u6cd5\u5f8b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52022\u5e7412\u670816\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5c07\u8207\u7f85\u6c0f\u958b\u5c55\u4e00\u9805\u96a8\u6a5f\u8de8\u570b\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5929\u6f14\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u55ae\u6297\uff08\u6297PD-L1\u55ae\u514b\u9686\u6297\u9ad4\uff09\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\uff08\u6297VEGF\u55ae\u514b\u9686\u6297\u9ad4\uff09\u4e4b\u4e09\u806f\u514d\u75ab\u7642\u6cd5\u91dd\u5c0d\u665a\u671f\u809d\u7d30\u80de\u764c\uff08hepatocellular carcinoma, HCC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\u3002\u672c\u6b21\u5408\u4f5c\u5c07\u4f7f\u7528\u7f85\u6c0f\u7684MORPHEUS-LIVER\u5e73\u53f0\uff0c\u4ee5\u5be6\u73fe\u5feb\u901f\u9ad8\u6548\u7684\u806f\u5408\u958b\u767c\u3002 \u672c\u6b21\u5408\u4f5c\u5c07\u7531\u7f85\u6c0f\u8cc7\u52a9\uff0c\u521d\u671f\u8a08\u5283\u572860\u540d\u665a\u671f\u809d\u764c\u60a3\u8005\u4e2d\u958b\u5c55\u96a8\u6a5fIb\/II\u671f\u8de8\u570b\u591a\u4e2d\u5fc3\u8a66\u9a57\uff0c\u8a55\u4f30ADG126\u8207\u8c9d\u4f10\u73e0\u55ae\u6297\u548c\u963f\u66ff\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5c0d\u7167\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u8207\u85e5\u4ee3\u52d5\u529b\u5b78\u3002\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5169\u5bb6\u516c\u53f8\u5c07\u63d0\u4f9b\u5404\u81ea\u7684\u6297\u764c\u85e5\u7269\u3002\u5929\u6f14\u5c07\u4fdd\u7559\u5c0dADG126\u7684\u5168\u7403\u958b\u767c\u8207\u5546\u54c1\u5316\u6b0a\u5229\u3002\u95dc\u65bc\u672c\u6b21\u5408\u4f5c\u7684\u5176\u4ed6\u8ca1\u52d9\u8a73\u60c5\u4e26\u672a\u516c\u4f48\u3002 \u672c\u6b21\u7814\u7a76\u5c07\u5929\u6f14\u7684\u5168\u7403ADG126\u81e8\u5e8a\u958b\u767c\u62d3\u5c55\u5230\u809d\u764c\u4e00\u7dda\u6cbb\u7642\uff0c\u6709\u671b\u6210\u70ba\u809d\u7d30\u80de\u764c\u4e00\u7dda\u806f\u5408\u7642\u6cd5\u4e2d\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002\u76ee\u524d\u6297CTLA-4\u8207\u6297PD-1\/PD-L1\u806f\u5408\u7642\u6cd5\u5df2\u5728\u81e8\u5e8a\u4e0a\u8868\u73fe\u51fa\u6709\u7d71\u8a08\u5b78\u5dee\u7570\u7684\u81e8\u5e8a\u7372\u76ca\u3002\u6b63\u5728\u9032\u884c\u4e2d\u7684Ib\/II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5df2\u8868\u660e\uff0c\u5728\u55ae\u4e00\u6cbb\u7642\u6700\u9ad8\u5291\u91cf20 mg\/kg\u91cd\u8907\u7d66\u85e5\u548c\u5728\u806f\u5408\u5291\u91cf\u9ad8\u905410 mg\/kg\u8207\u6297PD-1\u7684\u806f\u5408\u6cbb\u7642\u4e2d\uff0cADG126\u986f\u73fe\u51fa\u9ad8\u5ea6\u5dee\u7570\u5316\u7684\u5b89\u5168\u6027\u3002\u6191\u501f\u91cd\u8907\u7d66\u85e5\u5f8c\u512a\u7570\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u7a4d\u6975\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0cADG126\u975e\u5e38\u9069\u7528\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u91dd\u5c0d\u816b\u7624\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002 \u300c\u7f85\u6c0f\u958b\u767c\u7684\u96d9\u85e5\u806f\u5408\u7642\u6cd5\u662fFDA\u5be9\u6279\u901a\u904e\u7684\u809d\u764c\u7684\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u8207\u4ed6\u5011\u570d\u7e5e\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u958b\u555f\u672c\u6b21\u5408\u4f5c\uff0c\u5728\u73fe\u6709\u7684\u7a81\u7834\u6027\u7684\u4e8c\u91cd\u806f\u5408\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u4e4b\u5916\u63a2\u7d22\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5728\u4e09\u91cd\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\uff0c\u300d\u5929\u6f14\u806f\u5408\u5275\u59cb\u4eba\u3001\u9996\u5e2d\u57f7\u884c\u5b98\u517c\u8463\u4e8b\u9577\u7f85\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff0c\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u91dd\u5c0d\u809d\u764c\u7684\u591a\u85e5\u806f\u5408\u65b9\u6848\u4e00\u76f4\u9762\u81e8\u5b89\u5168\u6311\u6230\uff0c\u800c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5c55\u793a\u4e86\u6297CTLA-4\u7642\u6cd5\u524d\u6240\u672a\u6709\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5c07\u5176\u52a0\u5165\u4e09\u91cd\u514d\u75ab\u806f\u5408\u7642\u6cd5\u662f\u4e00\u500b\u9817\u5177\u524d\u666f\u7684\u809d\u764c\u6cbb\u7642\u7b56\u7565\uff0c\u6211\u5011\u5c0d\u6b64\u5145\u6eff\u671f\u5f85\u3002\u300d \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u53ef\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5f9e\u800c\u89e3\u6c7a\u773e\u591a\u6297\u9ad4\u7642\u6cd5\u9762\u81e8\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u6311\u6230\u3002\u5b89\u5168\u6297\u9ad4ADG126\u5c07\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297CTLA-4\u6297\u9ad4ADG116\uff0c\u4ee5\u5be6\u73fe\u5b89\u5168\u6297\u9ad4ADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\uff08therapeutic index\uff09\u5f9e\u800c\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u7642\u6cd5\u4e2d\u5b58\u5728\u7684\u5b89\u5168\u554f\u984c\u3002 \u63a9\u853d\u578bADG126\u6240\u7d50\u5408\u7684CTLA-4\u9776\u9ede\u7684\u7368\u7279\u8868\u4f4d\u8207ADG116\u76f8\u540c\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5728\u816b\u7624\u7d44\u7e54\u4e2d\u7684\u66b4\u9732\u5f9e\u800c\u589e\u5f37\u4f5c\u7528\uff0c\u4ee5\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u95dc\u65bc\u809d\u7d30\u80de\u764c \u809d\u764c\u662f\u5168\u7403\u7b2c\u4e94\u5e38\u898b\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u81f4\u6b7b\u75c5\u56e0\uff0c\u6bcf\u5e74\u65b0\u589e854,000\u500b\u75c5\u4f8b\uff0c\u9020\u6210810,000\u4eba\u6b7b\u4ea1\u3002\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u662f\u6700\u4e3b\u8981\u7684\u539f\u767c\u6027\u809d\u764c\uff0c\u5728\u6240\u6709\u539f\u767c\u6027\u809d\u81df\u60e1\u6027\u816b\u7624\u4e2d\u5360\u6bd4\u7d0490%\u3002\u7531\u65bc\u75c7\u72c0\u986f\u9732\u9072\u7de9\uff0c\u591a\u905480%\u7684\u809d\u7d30\u80de\u764c\u5728\u78ba\u8a3a\u5f8c\u6703\u767c\u5c55\u6210\u70ba\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u8f49\u79fb\u6027\u764c\u75c7\u3002\u7d55\u5927\u591a\u6578\u809d\u7d30\u80de\u764c\u60a3\u8005\u90fd\u4f34\u6709\u6f5b\u5728\u809d\u786c\u5316\u75c7\u72c0\uff0c\u9700\u8981\u540c\u6642\u6cbb\u7642\u60e1\u6027\u816b\u7624\u8207\u809d\u786c\u5316\uff0c\u56e0\u6b64\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u8907\u96dc\u96e3\u6cbb\u7684\u75be\u75c5\u3002\u5728\u7f8e\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\uff08OS\uff09\u7387\u70ba17%\uff08Siegel\u7b49\uff0c2016\u5e74\uff09\uff1b\u5728\u4e2d\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\u7387\u70ba10.1%\uff08Chen\u7b49\uff0c2016\u5e74\uff09\u3002\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u6975\u70ba\u81f4\u547d\u7684\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u8207\u767c\u75c5\u7387\u4e4b\u6bd4\u9054\u52300.98\uff0c\u5728\u5be6\u9ad4\u816b\u7624\u4e2d\u9ad8\u5c45\u7b2c\u4e00\uff08Kamangar\u7b49\uff0c2006\u5e74\uff09\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u4f30\u6e2c\uff0c2030\u5e74\u5c07\u6709\u8d85\u904e100\u842c\u4eba\u6b7b\u65bc\u809d\u764c\uff0c\u9020\u6210\u5168\u7403\u91cd\u5927\u516c\u5171\u885b\u751f\u554f\u984c\uff08Villanueva 2019\uff09\u3002 \u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b1995\u5e74\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u4e0b\u6240\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\uff0c\u5305\u62ecADG126\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u548c\u7f85\u6c0f\u4e4b\u9593\u5546\u696d\u5408\u4f5c\u5b89\u6392\u7684\u9810\u671f\u6536\u76ca\u548c\u6f5b\u529b\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1bCOVID-19 \u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u4ee520-F\u70ba\u5f62\u5f0f\u76842021\u5e74\u5ea6\u5831\u544a\u4e4b\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u6cd5\u5f8b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52022\u5e7412\u670816\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5c07\u8207\u7f85\u6c0f\u958b\u5c55\u4e00\u9805\u96a8\u6a5f\u8de8\u570b\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5929\u6f14\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u55ae\u6297\uff08\u6297PD-L1\u55ae\u514b\u9686\u6297\u9ad4\uff09\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\uff08\u6297VEGF\u55ae\u514b\u9686\u6297\u9ad4\uff09\u4e4b\u4e09\u806f\u514d\u75ab\u7642\u6cd5\u91dd\u5c0d\u665a\u671f\u809d\u7d30\u80de\u764c\uff08hepatocellular carcinoma, HCC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\u3002\u672c\u6b21\u5408\u4f5c\u5c07\u4f7f\u7528\u7f85\u6c0f\u7684MORPHEUS-LIVER\u5e73\u53f0\uff0c\u4ee5\u5be6\u73fe\u5feb\u901f\u9ad8\u6548\u7684\u806f\u5408\u958b\u767c\u3002 \u672c\u6b21\u5408\u4f5c\u5c07\u7531\u7f85\u6c0f\u8cc7\u52a9\uff0c\u521d\u671f\u8a08\u5283\u572860\u540d\u665a\u671f\u809d\u764c\u60a3\u8005\u4e2d\u958b\u5c55\u96a8\u6a5fIb\/II\u671f\u8de8\u570b\u591a\u4e2d\u5fc3\u8a66\u9a57\uff0c\u8a55\u4f30ADG126\u8207\u8c9d\u4f10\u73e0\u55ae\u6297\u548c\u963f\u66ff\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5c0d\u7167\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u8207\u85e5\u4ee3\u52d5\u529b\u5b78\u3002\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5169\u5bb6\u516c\u53f8\u5c07\u63d0\u4f9b\u5404\u81ea\u7684\u6297\u764c\u85e5\u7269\u3002\u5929\u6f14\u5c07\u4fdd\u7559\u5c0dADG126\u7684\u5168\u7403\u958b\u767c\u8207\u5546\u54c1\u5316\u6b0a\u5229\u3002\u95dc\u65bc\u672c\u6b21\u5408\u4f5c\u7684\u5176\u4ed6\u8ca1\u52d9\u8a73\u60c5\u4e26\u672a\u516c\u4f48\u3002 \u672c\u6b21\u7814\u7a76\u5c07\u5929\u6f14\u7684\u5168\u7403ADG126\u81e8\u5e8a\u958b\u767c\u62d3\u5c55\u5230\u809d\u764c\u4e00\u7dda\u6cbb\u7642\uff0c\u6709\u671b\u6210\u70ba\u809d\u7d30\u80de\u764c\u4e00\u7dda\u806f\u5408\u7642\u6cd5\u4e2d\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002\u76ee\u524d\u6297CTLA-4\u8207\u6297PD-1\/PD-L1\u806f\u5408\u7642\u6cd5\u5df2\u5728\u81e8\u5e8a\u4e0a\u8868\u73fe\u51fa\u6709\u7d71\u8a08\u5b78\u5dee\u7570\u7684\u81e8\u5e8a\u7372\u76ca\u3002\u6b63\u5728\u9032\u884c\u4e2d\u7684Ib\/II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5df2\u8868\u660e\uff0c\u5728\u55ae\u4e00\u6cbb\u7642\u6700\u9ad8\u5291\u91cf20 mg\/kg\u91cd\u8907\u7d66\u85e5\u548c\u5728\u806f\u5408\u5291\u91cf\u9ad8\u905410 mg\/kg\u8207\u6297PD-1\u7684\u806f\u5408\u6cbb\u7642\u4e2d\uff0cADG126\u986f\u73fe\u51fa\u9ad8\u5ea6\u5dee\u7570\u5316\u7684\u5b89\u5168\u6027\u3002\u6191\u501f\u91cd\u8907\u7d66\u85e5\u5f8c\u512a\u7570\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u7a4d\u6975\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0cADG126\u975e\u5e38\u9069\u7528\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u91dd\u5c0d\u816b\u7624\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002 \u300c\u7f85\u6c0f\u958b\u767c\u7684\u96d9\u85e5\u806f\u5408\u7642\u6cd5\u662fFDA\u5be9\u6279\u901a\u904e\u7684\u809d\u764c\u7684\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u8207\u4ed6\u5011\u570d\u7e5e\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u958b\u555f\u672c\u6b21\u5408\u4f5c\uff0c\u5728\u73fe\u6709\u7684\u7a81\u7834\u6027\u7684\u4e8c\u91cd\u806f\u5408\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u4e4b\u5916\u63a2\u7d22\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5728\u4e09\u91cd\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\uff0c\u300d\u5929\u6f14\u806f\u5408\u5275\u59cb\u4eba\u3001\u9996\u5e2d\u57f7\u884c\u5b98\u517c\u8463\u4e8b\u9577\u7f85\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff0c\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u91dd\u5c0d\u809d\u764c\u7684\u591a\u85e5\u806f\u5408\u65b9\u6848\u4e00\u76f4\u9762\u81e8\u5b89\u5168\u6311\u6230\uff0c\u800c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5c55\u793a\u4e86\u6297CTLA-4\u7642\u6cd5\u524d\u6240\u672a\u6709\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5c07\u5176\u52a0\u5165\u4e09\u91cd\u514d\u75ab\u806f\u5408\u7642\u6cd5\u662f\u4e00\u500b\u9817\u5177\u524d\u666f\u7684\u809d\u764c\u6cbb\u7642\u7b56\u7565\uff0c\u6211\u5011\u5c0d\u6b64\u5145\u6eff\u671f\u5f85\u3002\u300d \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u53ef\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5f9e\u800c\u89e3\u6c7a\u773e\u591a\u6297\u9ad4\u7642\u6cd5\u9762\u81e8\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u6311\u6230\u3002\u5b89\u5168\u6297\u9ad4ADG126\u5c07\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297CTLA-4\u6297\u9ad4ADG116\uff0c\u4ee5\u5be6\u73fe\u5b89\u5168\u6297\u9ad4ADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\uff08therapeutic index\uff09\u5f9e\u800c\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u7642\u6cd5\u4e2d\u5b58\u5728\u7684\u5b89\u5168\u554f\u984c\u3002 \u63a9\u853d\u578bADG126\u6240\u7d50\u5408\u7684CTLA-4\u9776\u9ede\u7684\u7368\u7279\u8868\u4f4d\u8207ADG116\u76f8\u540c\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5728\u816b\u7624\u7d44\u7e54\u4e2d\u7684\u66b4\u9732\u5f9e\u800c\u589e\u5f37\u4f5c\u7528\uff0c\u4ee5\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u95dc\u65bc\u809d\u7d30\u80de\u764c \u809d\u764c\u662f\u5168\u7403\u7b2c\u4e94\u5e38\u898b\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u81f4\u6b7b\u75c5\u56e0\uff0c\u6bcf\u5e74\u65b0\u589e854,000\u500b\u75c5\u4f8b\uff0c\u9020\u6210810,000\u4eba\u6b7b\u4ea1\u3002\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u662f\u6700\u4e3b\u8981\u7684\u539f\u767c\u6027\u809d\u764c\uff0c\u5728\u6240\u6709\u539f\u767c\u6027\u809d\u81df\u60e1\u6027\u816b\u7624\u4e2d\u5360\u6bd4\u7d0490%\u3002\u7531\u65bc\u75c7\u72c0\u986f\u9732\u9072\u7de9\uff0c\u591a\u905480%\u7684\u809d\u7d30\u80de\u764c\u5728\u78ba\u8a3a\u5f8c\u6703\u767c\u5c55\u6210\u70ba\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u8f49\u79fb\u6027\u764c\u75c7\u3002\u7d55\u5927\u591a\u6578\u809d\u7d30\u80de\u764c\u60a3\u8005\u90fd\u4f34\u6709\u6f5b\u5728\u809d\u786c\u5316\u75c7\u72c0\uff0c\u9700\u8981\u540c\u6642\u6cbb\u7642\u60e1\u6027\u816b\u7624\u8207\u809d\u786c\u5316\uff0c\u56e0\u6b64\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u8907\u96dc\u96e3\u6cbb\u7684\u75be\u75c5\u3002\u5728\u7f8e\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\uff08OS\uff09\u7387\u70ba17%\uff08Siegel\u7b49\uff0c2016\u5e74\uff09\uff1b\u5728\u4e2d\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\u7387\u70ba10.1%\uff08Chen\u7b49\uff0c2016\u5e74\uff09\u3002\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u6975\u70ba\u81f4\u547d\u7684\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u8207\u767c\u75c5\u7387\u4e4b\u6bd4\u9054\u52300.98\uff0c\u5728\u5be6\u9ad4\u816b\u7624\u4e2d\u9ad8\u5c45\u7b2c\u4e00\uff08Kamangar\u7b49\uff0c2006\u5e74\uff09\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u4f30\u6e2c\uff0c2030\u5e74\u5c07\u6709\u8d85\u904e100\u842c\u4eba\u6b7b\u65bc\u809d\u764c\uff0c\u9020\u6210\u5168\u7403\u91cd\u5927\u516c\u5171\u885b\u751f\u554f\u984c\uff08Villanueva 2019\uff09\u3002 \u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b1995\u5e74\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u4e0b\u6240\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\uff0c\u5305\u62ecADG126\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u548c\u7f85\u6c0f\u4e4b\u9593\u5546\u696d\u5408\u4f5c\u5b89\u6392\u7684\u9810\u671f\u6536\u76ca\u548c\u6f5b\u529b\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1bCOVID-19 \u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u4ee520-F\u70ba\u5f62\u5f0f\u76842021\u5e74\u5ea6\u5831\u544a\u4e4b\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u6cd5\u5f8b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\" \/>\n<meta property=\"og:site_name\" content=\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-16T03:31:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\",\"datePublished\":\"2022-12-16T03:31:00+00:00\",\"dateModified\":\"2022-12-16T03:31:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\"},\"wordCount\":59,\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"articleSection\":[\"\u672a\u5206\u985e\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\",\"url\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\",\"name\":\"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\"},\"datePublished\":\"2022-12-16T03:31:00+00:00\",\"dateModified\":\"2022-12-16T03:31:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\/\/www.franchise.com.hk\/en\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"description\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK\",\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.franchise.com.hk\/en?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\",\"url\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"width\":350,\"height\":76,\"caption\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\"},\"image\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252","og_locale":"en_US","og_type":"article","og_title":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","og_description":"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52022\u5e7412\u670816\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5c07\u8207\u7f85\u6c0f\u958b\u5c55\u4e00\u9805\u96a8\u6a5f\u8de8\u570b\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5929\u6f14\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u55ae\u6297\uff08\u6297PD-L1\u55ae\u514b\u9686\u6297\u9ad4\uff09\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\uff08\u6297VEGF\u55ae\u514b\u9686\u6297\u9ad4\uff09\u4e4b\u4e09\u806f\u514d\u75ab\u7642\u6cd5\u91dd\u5c0d\u665a\u671f\u809d\u7d30\u80de\u764c\uff08hepatocellular carcinoma, HCC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\u3002\u672c\u6b21\u5408\u4f5c\u5c07\u4f7f\u7528\u7f85\u6c0f\u7684MORPHEUS-LIVER\u5e73\u53f0\uff0c\u4ee5\u5be6\u73fe\u5feb\u901f\u9ad8\u6548\u7684\u806f\u5408\u958b\u767c\u3002 \u672c\u6b21\u5408\u4f5c\u5c07\u7531\u7f85\u6c0f\u8cc7\u52a9\uff0c\u521d\u671f\u8a08\u5283\u572860\u540d\u665a\u671f\u809d\u764c\u60a3\u8005\u4e2d\u958b\u5c55\u96a8\u6a5fIb\/II\u671f\u8de8\u570b\u591a\u4e2d\u5fc3\u8a66\u9a57\uff0c\u8a55\u4f30ADG126\u8207\u8c9d\u4f10\u73e0\u55ae\u6297\u548c\u963f\u66ff\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5c0d\u7167\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u8207\u85e5\u4ee3\u52d5\u529b\u5b78\u3002\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5169\u5bb6\u516c\u53f8\u5c07\u63d0\u4f9b\u5404\u81ea\u7684\u6297\u764c\u85e5\u7269\u3002\u5929\u6f14\u5c07\u4fdd\u7559\u5c0dADG126\u7684\u5168\u7403\u958b\u767c\u8207\u5546\u54c1\u5316\u6b0a\u5229\u3002\u95dc\u65bc\u672c\u6b21\u5408\u4f5c\u7684\u5176\u4ed6\u8ca1\u52d9\u8a73\u60c5\u4e26\u672a\u516c\u4f48\u3002 \u672c\u6b21\u7814\u7a76\u5c07\u5929\u6f14\u7684\u5168\u7403ADG126\u81e8\u5e8a\u958b\u767c\u62d3\u5c55\u5230\u809d\u764c\u4e00\u7dda\u6cbb\u7642\uff0c\u6709\u671b\u6210\u70ba\u809d\u7d30\u80de\u764c\u4e00\u7dda\u806f\u5408\u7642\u6cd5\u4e2d\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002\u76ee\u524d\u6297CTLA-4\u8207\u6297PD-1\/PD-L1\u806f\u5408\u7642\u6cd5\u5df2\u5728\u81e8\u5e8a\u4e0a\u8868\u73fe\u51fa\u6709\u7d71\u8a08\u5b78\u5dee\u7570\u7684\u81e8\u5e8a\u7372\u76ca\u3002\u6b63\u5728\u9032\u884c\u4e2d\u7684Ib\/II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5df2\u8868\u660e\uff0c\u5728\u55ae\u4e00\u6cbb\u7642\u6700\u9ad8\u5291\u91cf20 mg\/kg\u91cd\u8907\u7d66\u85e5\u548c\u5728\u806f\u5408\u5291\u91cf\u9ad8\u905410 mg\/kg\u8207\u6297PD-1\u7684\u806f\u5408\u6cbb\u7642\u4e2d\uff0cADG126\u986f\u73fe\u51fa\u9ad8\u5ea6\u5dee\u7570\u5316\u7684\u5b89\u5168\u6027\u3002\u6191\u501f\u91cd\u8907\u7d66\u85e5\u5f8c\u512a\u7570\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u7a4d\u6975\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0cADG126\u975e\u5e38\u9069\u7528\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u91dd\u5c0d\u816b\u7624\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002 \u300c\u7f85\u6c0f\u958b\u767c\u7684\u96d9\u85e5\u806f\u5408\u7642\u6cd5\u662fFDA\u5be9\u6279\u901a\u904e\u7684\u809d\u764c\u7684\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u8207\u4ed6\u5011\u570d\u7e5e\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u958b\u555f\u672c\u6b21\u5408\u4f5c\uff0c\u5728\u73fe\u6709\u7684\u7a81\u7834\u6027\u7684\u4e8c\u91cd\u806f\u5408\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u4e4b\u5916\u63a2\u7d22\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5728\u4e09\u91cd\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\uff0c\u300d\u5929\u6f14\u806f\u5408\u5275\u59cb\u4eba\u3001\u9996\u5e2d\u57f7\u884c\u5b98\u517c\u8463\u4e8b\u9577\u7f85\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff0c\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u91dd\u5c0d\u809d\u764c\u7684\u591a\u85e5\u806f\u5408\u65b9\u6848\u4e00\u76f4\u9762\u81e8\u5b89\u5168\u6311\u6230\uff0c\u800c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5c55\u793a\u4e86\u6297CTLA-4\u7642\u6cd5\u524d\u6240\u672a\u6709\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5c07\u5176\u52a0\u5165\u4e09\u91cd\u514d\u75ab\u806f\u5408\u7642\u6cd5\u662f\u4e00\u500b\u9817\u5177\u524d\u666f\u7684\u809d\u764c\u6cbb\u7642\u7b56\u7565\uff0c\u6211\u5011\u5c0d\u6b64\u5145\u6eff\u671f\u5f85\u3002\u300d \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u53ef\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5f9e\u800c\u89e3\u6c7a\u773e\u591a\u6297\u9ad4\u7642\u6cd5\u9762\u81e8\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u6311\u6230\u3002\u5b89\u5168\u6297\u9ad4ADG126\u5c07\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297CTLA-4\u6297\u9ad4ADG116\uff0c\u4ee5\u5be6\u73fe\u5b89\u5168\u6297\u9ad4ADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\uff08therapeutic index\uff09\u5f9e\u800c\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u7642\u6cd5\u4e2d\u5b58\u5728\u7684\u5b89\u5168\u554f\u984c\u3002 \u63a9\u853d\u578bADG126\u6240\u7d50\u5408\u7684CTLA-4\u9776\u9ede\u7684\u7368\u7279\u8868\u4f4d\u8207ADG116\u76f8\u540c\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5728\u816b\u7624\u7d44\u7e54\u4e2d\u7684\u66b4\u9732\u5f9e\u800c\u589e\u5f37\u4f5c\u7528\uff0c\u4ee5\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u95dc\u65bc\u809d\u7d30\u80de\u764c \u809d\u764c\u662f\u5168\u7403\u7b2c\u4e94\u5e38\u898b\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u81f4\u6b7b\u75c5\u56e0\uff0c\u6bcf\u5e74\u65b0\u589e854,000\u500b\u75c5\u4f8b\uff0c\u9020\u6210810,000\u4eba\u6b7b\u4ea1\u3002\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u662f\u6700\u4e3b\u8981\u7684\u539f\u767c\u6027\u809d\u764c\uff0c\u5728\u6240\u6709\u539f\u767c\u6027\u809d\u81df\u60e1\u6027\u816b\u7624\u4e2d\u5360\u6bd4\u7d0490%\u3002\u7531\u65bc\u75c7\u72c0\u986f\u9732\u9072\u7de9\uff0c\u591a\u905480%\u7684\u809d\u7d30\u80de\u764c\u5728\u78ba\u8a3a\u5f8c\u6703\u767c\u5c55\u6210\u70ba\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u8f49\u79fb\u6027\u764c\u75c7\u3002\u7d55\u5927\u591a\u6578\u809d\u7d30\u80de\u764c\u60a3\u8005\u90fd\u4f34\u6709\u6f5b\u5728\u809d\u786c\u5316\u75c7\u72c0\uff0c\u9700\u8981\u540c\u6642\u6cbb\u7642\u60e1\u6027\u816b\u7624\u8207\u809d\u786c\u5316\uff0c\u56e0\u6b64\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u8907\u96dc\u96e3\u6cbb\u7684\u75be\u75c5\u3002\u5728\u7f8e\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\uff08OS\uff09\u7387\u70ba17%\uff08Siegel\u7b49\uff0c2016\u5e74\uff09\uff1b\u5728\u4e2d\u570b\uff0c\u809d\u7d30\u80de\u764c\u60a3\u8005\u57285\u5e74\u5167\u7684\u7e3d\u9ad4\u5b58\u6d3b\u7387\u70ba10.1%\uff08Chen\u7b49\uff0c2016\u5e74\uff09\u3002\u809d\u7d30\u80de\u764c\u662f\u4e00\u7a2e\u6975\u70ba\u81f4\u547d\u7684\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u8207\u767c\u75c5\u7387\u4e4b\u6bd4\u9054\u52300.98\uff0c\u5728\u5be6\u9ad4\u816b\u7624\u4e2d\u9ad8\u5c45\u7b2c\u4e00\uff08Kamangar\u7b49\uff0c2006\u5e74\uff09\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u4f30\u6e2c\uff0c2030\u5e74\u5c07\u6709\u8d85\u904e100\u842c\u4eba\u6b7b\u65bc\u809d\u764c\uff0c\u9020\u6210\u5168\u7403\u91cd\u5927\u516c\u5171\u885b\u751f\u554f\u984c\uff08Villanueva 2019\uff09\u3002 \u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b1995\u5e74\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u4e0b\u6240\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\uff0c\u5305\u62ecADG126\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u548c\u7f85\u6c0f\u4e4b\u9593\u5546\u696d\u5408\u4f5c\u5b89\u6392\u7684\u9810\u671f\u6536\u76ca\u548c\u6f5b\u529b\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1bCOVID-19 \u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u4ee520-F\u70ba\u5f62\u5f0f\u76842021\u5e74\u5ea6\u5831\u544a\u4e4b\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u6cd5\u5f8b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002","og_url":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252","og_site_name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","article_published_time":"2022-12-16T03:31:00+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#article","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252"},"author":{"name":"","@id":""},"headline":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c","datePublished":"2022-12-16T03:31:00+00:00","dateModified":"2022-12-16T03:31:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252"},"wordCount":59,"publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"articleSection":["\u672a\u5206\u985e"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252","url":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252","name":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en#website"},"datePublished":"2022-12-16T03:31:00+00:00","dateModified":"2022-12-16T03:31:00+00:00","breadcrumb":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.franchise.com.hk\/en\/%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%e5%ae%a3%e4%bd%88%e8%88%87%e7%be%85%e6%b0%8f%e9%96%8b%e5%b1%95%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e5%90%88%e4%bd%9c%ef%bc%8c%e8%a9%95%e4%bc%b0%e5%85%b6%e6%8a%97ct\/10252#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/www.franchise.com.hk\/en"},{"@type":"ListItem","position":2,"name":"\u5929\u6f14\u85e5\u696d\u5ba3\u4f48\u8207\u7f85\u6c0f\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\uff0c\u8a55\u4f30\u5176\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u806f\u5408\u7f85\u6c0f\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c"}]},{"@type":"WebSite","@id":"https:\/\/www.franchise.com.hk\/en#website","url":"https:\/\/www.franchise.com.hk\/en","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","description":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK","publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.franchise.com.hk\/en?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.franchise.com.hk\/en#organization","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","url":"https:\/\/www.franchise.com.hk\/en","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","width":350,"height":76,"caption":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df"},"image":{"@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/"}}]}},"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/10252"}],"collection":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/comments?post=10252"}],"version-history":[{"count":0,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/10252\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/media?parent=10252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/categories?post=10252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/tags?post=10252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}